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This part of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you need to err to the side of caution and allow FDA do its job and demand some investigation be done in order that the public knows the side effects and hazards of the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on the medications. Researchers found out that participants investing in this drug for the year, lost excess weight within four weeks and have kept the weight off throughout the 56 weeks with the study. Contrave is really a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, which can make them more efficient and safer. Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that by right now there are not any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure and heart rate, and shouldn't be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. "This could be the first drug I'm aware of that targets both the appetite and reward centres in the brain," he explained.