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It must be used in combination with a low-calorie diet and physical exercise in order to be effective. Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done so the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on their medications. Researchers discovered that participants investing in this drug for the year, lost excess weight within a month and have kept the body weight off during the entire 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which might be made up of multiple active ingredient, which might make them more potent and safer. Combo-pilling could be the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular could be the fact that at the time of right now there are no long term prescription slimming capsules that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and shouldn't be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not be used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking. Most of the combinations which might be used to enhance weight loss involve an amphetamine with an antidepressant. Phentermine and Prozac are a popular combination which were around for a while, and even though it has been around stuffed to truly combine both and try to get FDA approval to advertise it as a weight reduction pill. Right there should raise some warning flags if the greedy pharmaceutical companies do not want to be involved in combining medications and selling them something have to be wrong with the combination. In fairness there exists one weight loss combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, used to treat alcohol and abusing drugs, with all the antidepressant bupropion (Wellbutrin, Zyban) many experts have given the go ahead to move forward by an FDA advisory committee, but since yet hasn't been approved.