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David Becker, a Pennsylvanian cardiologist, red yeast rice works as good as statin drugs to lower cholesterol. To check possible drug to drug interactions with Crestor, you can check the Drugs. But in light of my doctor's fervent pleas (and office co-pay), and my fiancee's (now wife's) are a symbol of "as long because you both shall live" being as long as possible, I will tend to err around the side of caution. Tell your caregiver what Herbal supplements you're taking and what foods you take in often. This has led on the development of many red yeast rice products that have been marketed as natural food items for cholesterol reduction. Issues and Risks of Taking Crestor as Your Cholesterol Lowering Medication. Your physician will regularly monitor your liver function should you have liver disease or ever have stood a liver disease sucha s hepatitis. Other less noted unwanted effects of CRESTOR are sexual dysfunction, irritability, performance problems, and personality changes. 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